Comparative Efficacy Study of N-Chromosome Royal Jelly Versus Semelil (ANGIPARS) on Wound Healing of Diabetic Rats

Comparative Efficacy Study of N-Chromosome Royal Jelly Versus Semelil (ANGIPARS) on Wound Healing of Diabetic Rats

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Objective: The healing effects of two different dilutions (5 & 100%) of N-Chromosome Royal Jelly and ANGIPARS ointment were investigated and measured on experimental injuries in streptozotocin (STZ)-induced diabetic rats.This study investigated the healing effects of 2 different N Chromosome Royal Jelly dilutions on injuries of Eyeliner STZ-induced diabetic rats.Materials and Methods: For diabetes induction, male Wistar rats received STZ (55 mg/kg) intraperitoneally and plasma glucose level measurement after 72 hours demonstrated diabetes induction.Rats were randomly divided into 5 groups of 6 members and one square centimeter (cm2) wound was surgically induced in the dorsal region of each rat.The test groups were treated with ANGIPARS, undiluted royal jelly N chromosome, and royal jelly N chromosome 5% separately.

The control groups were including non-diabetic and untreated diabetic rats.Results: The findings indicate a significant acceleration in wound healing of the diabetic rats treated by ANGIPARS ointment or royal jelly N chromosomes 5%.RJ also shortened the healing period of desquamated skin lesions.Thus, RJ possesses an anti-inflammatory action and is able to augment wound healing, but does not have an insulin-like action in streptozotocin-diabetic rats.Conclusion: Regarding the mentioned findings, royal jelly as a natural product may play an effective Heat Lamps role in treating chronic wounds in mice, which makes it a proper candidate for use in human wound repair.

Nonetheless, it seems that determination of the suitable dilution of this compound will result in better effects, thus more studies are recommended.